Each two-capsule serving of JointBrex lists eight ingredients with exact amounts.
Glucosamine sulfate 1,000 mg, boswellia extract 133.3 mg, chondroitin sulfate 100 mg and turmeric root 100 mg lead, with quercetin, methionine, MSM and bromelain at 16.7 mg each. It contains crustacean shellfish (crayfish).
Eight ingredients, every amount printed on the bottle.
JointBrex lists eight active ingredients on its label. Two capsules give glucosamine sulfate 1,000 mg, boswellia extract 133.3 mg, chondroitin sulfate 100 mg and turmeric root 100 mg. Then come four small extras: quercetin, methionine, MSM and bromelain, at 16.7 mg each.
Added up, that is about 1,400 mg of active ingredients a day. Glucosamine alone makes up about 71% of it. So this is mainly a glucosamine product with smaller helpers around it.
This page lists every ingredient with its amount, explains each one in plain words, and compares each amount with the doses used in research.
Glucosamine is the main ingredient by a wide margin.
Here is the full list from the Supplement Facts panel, in label order. The amounts are per serving of two vegetable capsules. The last column shows each ingredient's share of the total active weight. We worked that out from the label numbers.
JointBrex label, per serving of 2 capsules
| Ingredient (label name) | Per 2 capsules | Share of active weight |
|---|---|---|
| Glucosamine sulfate | 1,000 mg | About 71% |
| Boswellia extract (Boswellia serrata, resin) | 133.3 mg | About 9.5% |
| Chondroitin sulfate | 100 mg | About 7% |
| Turmeric (Curcuma longa, root) | 100 mg | About 7% |
| Quercetin (Sophora japonica, bud) | 16.7 mg | About 1.2% |
| Methionine | 16.7 mg | About 1.2% |
| MSM (methylsulfonylmethane) | 16.7 mg | About 1.2% |
| Bromelain (Ananas comosus, stem) | 16.7 mg | About 1.2% |
For the panel itself, line by line, see the JointBrex supplement facts page.
Front: what it is. Back: what research found.
Each card has two sides. The front says what the ingredient is and how much is in a serving. The back gives the main research finding. Use the link on the back for the full ingredient page.
The largest ingredient, about 71% of the active weight. Usually made from shellfish shells.
Tap to see the research ↻GAIT used 1,500 mg a day and did not beat placebo overall (Clegg et al., 2006 (GAIT, NEJM)).
The 2019 ACR guideline strongly recommends against it for knee and hip OA (ACR/Arthritis Foundation guideline, 2019).
Full Glucosamine sulfate page →Tap to flip back ↺
A natural part of cartilage. Here it is a small add-in.
Tap to see the research ↻Trials used 800–1,200 mg a day (Wandel et al., BMJ 2010). Cochrane found a small short-term pain change in mostly low-quality trials (Singh et al., Cochrane 2015 (chondroitin)).
JointBrex: 100 mg, about 8% of 1,200 mg.
Full Chondroitin sulfate page →Tap to flip back ↺
Extract of frankincense resin from the Boswellia serrata tree.
Tap to see the research ↻Pooled trials used 100–250 mg of extract and found pain gains, but trial quality varied a lot (Yu et al., 2020).
JointBrex sits inside that range by weight.
Full Boswellia extract page →Tap to flip back ↺
Plain ground root of Curcuma longa, the yellow kitchen spice.
Tap to see the research ↻NCCIH calls early knee results encouraging but not yet proven (NCCIH, Turmeric, 2025).
Meta-analysis authors cite about 1,000 mg of curcumin a day (Daily et al., 2016).
Full Turmeric root page →Tap to flip back ↺
Four small add-ins that together weigh 66.8 mg.
Tap to see the research ↻MSM was studied at 3,375 mg a day (Debbi et al., 2011 (MSM RCT)); bromelain at 540 mg or more (Brien et al., 2004 (bromelain review)).
At 16.7 mg each, these are very small amounts.
Full Quercetin, methionine, MSM, bromelain page →Tap to flip back ↺
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Two fillers and one allergen line to read closely.
The other ingredients are cellulose, which forms the vegetable capsule, and rice flour, a common filler. The label also says: "Contains: Crustacean shellfish (crayfish)."
That line matters. Glucosamine in supplements is usually made from the shells of shellfish (LiverTox, Glucosamine, 2018). U.S. law treats crustacean shellfish as a major allergen and requires the type, here crayfish, to be named (FDA Food Allergies (crustacean shellfish), 2026).
Allergists say the risk of a reaction to glucosamine is likely very low, but not zero (Food Allergy Canada, Ask the allergist, 2023). Our post on glucosamine and shellfish allergy covers this in more detail.
One ingredient in range, one close, six small.
Only one of them is. Boswellia is inside the studied range by weight. Glucosamine is a bit under the usual dose. The rest are well below what research used. The bars show each label amount as a share of a typical research dose.
Label amount as a share of a research dose (calculated)
Label vs research doses
| Ingredient | JointBrex | Research dose | Source |
|---|---|---|---|
| Glucosamine sulfate | 1,000 mg | 1,500 mg a day | Clegg et al., 2006 (GAIT, NEJM) |
| Chondroitin sulfate | 100 mg | 800–1,200 mg a day | Wandel et al., BMJ 2010 |
| Boswellia extract | 133.3 mg | 100–250 mg a day | Yu et al., 2020 |
| Turmeric root | 100 mg | About 1,000 mg curcumin a day | Daily et al., 2016 |
| MSM | 16.7 mg | 3,375 mg a day | Debbi et al., 2011 (MSM RCT) |
| Bromelain | 16.7 mg | 540–1,890 mg a day | Brien et al., 2004 (bromelain review) |
| Quercetin | 16.7 mg | 500 mg a day judged safe | VKM (Norway) quercetin & rutin risk assessment |
| Methionine | 16.7 mg | No joint dose found | Label only |
One more detail. The label does not say how the boswellia extract is standardized, so we can't match it to a specific trial extract.
Six names and no numbers on one; eight names with numbers on the other.
The brand's sales page shows six ingredients, but no amounts at all. It leaves out quercetin and methionine, which are on the label. It also calls the turmeric "curcumin", while the label says plain root.
None of this changes what is in the bottle. It just means the label is the source to trust. Here is how the two compare.
Best for boswellia and turmeric. Weakest for glucosamine and chondroitin.
The evidence is mixed, and it is weakest for the main ingredient. The 2019 American College of Rheumatology guideline strongly recommends against glucosamine and chondroitin for knee and hip osteoarthritis (ACR/Arthritis Foundation guideline, 2019). Its 2026 update keeps that advice and adds the hand (ACR OA guideline update summary, 2026).
Boswellia and turmeric look more promising, but their trials are small and vary a lot. No study has tested the JointBrex formula itself.
Evidence by ingredient
| Ingredient | What research found | Plain rating |
|---|---|---|
| Glucosamine | Did not beat placebo in GAIT; pooled effects below what patients notice (Wandel et al., BMJ 2010) | Weak, guideline against |
| Chondroitin | Small short-term pain change in low-quality trials (Singh et al., Cochrane 2015 (chondroitin)) | Weak, guideline against |
| Boswellia | May reduce pain; larger studies needed (NCCIH Boswellia, 2025) | Promising, mixed |
| Turmeric | Encouraging early knee results (NCCIH, Turmeric, 2025) | Early |
| MSM, bromelain, quercetin | Very little research for joints (NCCIH, Bromelain, 2024) | Thin |
What does have strong evidence? Exercise and weight loss. Our joint pain guide explains simple ways to start.
If you take a blood thinner, five of these ingredients matter: glucosamine, turmeric, bromelain, quercetin and boswellia (HSA Singapore, Warfarin-glucosamine, 2009). Read joint supplements and blood thinners and the JointBrex side effects page before you start.
Two minutes with the bottle in good light.
Names like "joint brex gold", "joint rex" and "joint rx" are other products or versions. This page covers JointBrex Premium, 60 capsules. A quick check of your bottle settles it.
Look for JointBrex Premium and 60 Capsules on the front label.
Turn the bottle to the Supplement Facts box. Glucosamine sulfate 1,000 mg should be the first line.
Below the panel, look for crustacean shellfish (crayfish).
The label says two capsules daily before a meal. See how to use JointBrex.
Two capsules list eight ingredients: glucosamine sulfate 1,000 mg, boswellia extract 133.3 mg, chondroitin sulfate 100 mg, turmeric root 100 mg, and 16.7 mg each of quercetin, methionine, MSM and bromelain. The other ingredients are a cellulose capsule and rice flour.
Yes. The label says "Contains: Crustacean shellfish (crayfish)." Glucosamine is usually made from shellfish shells (LiverTox, Glucosamine, 2018). If you have a shellfish allergy, talk to an allergist before you take it.
There is 1,000 mg of glucosamine sulfate in two capsules, the daily serving on the label. Most trials used 1,500 mg a day, so the label dose is about two thirds of the usual studied amount.
It has turmeric root, 100 mg per serving. The label says root, not curcumin extract. Root powder is only partly curcumin, so the curcumin dose is much smaller than the 100 mg figure.
Yes, 16.7 mg per serving. The one MSM knee trial used 3,375 mg a day (Debbi et al., 2011 (MSM RCT)), so the JointBrex amount is about 0.5% of that dose.
We don't know why. The sales page names six ingredients with no amounts and leaves out quercetin and methionine. The bottle label is the better source, and this page follows the label.
Most side effects reported for these ingredients are mild, like stomach upset. The main checks are shellfish allergy, blood thinners such as warfarin, and blood sugar if you have diabetes. Read JointBrex side effects first.
No. The capsule shell is vegetable cellulose, but glucosamine comes from crayfish shell, as the allergen line shows. Chondroitin is also usually taken from animal cartilage.
We can't confirm that. This site covers JointBrex Premium, 60 capsules, with the label shown on this page. If your bottle says Gold or another name, compare its own Supplement Facts panel.
Order from the U.S. authorized merchant, keep your order email, and you are covered by the 60-day money-back guarantee. Questions first? Call +1 (302) 200-3480.
The Supplement Facts panel line by line, plus the label text, the allergen line and the front claim.
Read more →1,000 mg from crayfish shell; GAIT, Wandel and the ACR guideline; warfarin, blood sugar and eye pressure.
Read more →Every JointBrex caution in one place: stomach, shellfish, blood thinners, blood sugar, liver, stop signs.
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